Randi et al. 2023

Neural signal propagation atlas of Caenorhabditis elegans

Randi, F., Sharma, A.K., Dvali, S., Leifer, M.
Nature 623, 406–414 (2023)

Datasets incorporated

• Functional connectome from WormNeuroAtlas
• Anatomical connectome from WormNeuroAtlas

Resources from publication

• WormNeuroAtlas package
• FunCoNN: Functional Connectivity on NemaNode
• FunSim: Functional Connectivity Neuron Simulator
• Data on OSF

Summary

• Aims to understand the relationship between structure and function of the connectome by measuring signal propagation of C.elegans using direct optogenetic activation and simultaneous whole-brain calcium imaging
• The functional atlas is built upon:
  • anatomical datasets (White et al. 1986; Witvliet et al. 2021)
  • genome WormBase
  • single-cell transcriptome (Taylor et al. 2021)
  • neuropeptide/GPCR deorphanization (Beets et al. 2023)
  • monoaminergic connectome (Bentley et al. 2016)
  • neuropeptidergic connectome (Ripoll-Sanchez et al. 2023)