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MCL

MCL: Marginal Cell Neuron (pharynx) Left

Pharyngeal neurons that synapse onto marginal cells      Lineage: AB alpaaappp

Cook 2019 classification: Pharyngeal polymodal neuron      All cells of type: Polymodal neuron

Info on WormAtlas View in 3D on Open Source Brain

Summary of connections

Top 5 connections of specified types to/from this cell (based on Cook2019 Herm, Bentley2016_MA, RipollSanchezShortRange, Randi2023 & Brittin2021)

Electrical M2L 1
  ↕
Chemical MI 3, I1R 3, I1L 2, I3 1, I2R 1 ↘ MCL ↗ mc2V 13, mc2DR 7
MonoaminergicHSNL 1, HSNR 1, NSML 1, NSMR 1, RIML 1→→
Peptidergic MI 1, I3 1, I4 1, M5 1, M4 1→→I5 1, MI 1, M3L 1, M3R 1
Functional NSMR 0.2019, M3L 0.1588, M3R 0.1229, I4 0.1164→→NSMR 0.318, I2L 0.2947, NSML 0.2582, I2R 0.2013, BAGL 0.1589
  ↕
Contactomic

Chemical synaptic connections to MCL

I1R→MCLMI→MCLI1L→MCLI3→MCLI2R→MCLM4→MCLM3R→MCLM3L→MCL01234
DatasetWhite_wholeCook2019 HermCook2019 MaleCook2020ConnectionWeight
White_whole Cook2019 Herm Cook2019 Male Cook2020
I1R→MCL 2 3 3 4
MI→MCL 0 3 3 2.5
I1L→MCL 2 2 2 2
I3→MCL 1 1 1 2.5
I2R→MCL 0 1 1 0.5
M4→MCL 0 1 1 0.5
M3R→MCL 0 0 0 1
M3L→MCL 0 0 0 0.5

Chemical synaptic connections from MCL

MCL→mc2VMCL→mc2DR24681012
DatasetCook2019 HermCook2019 MaleCook2020ConnectionWeight
Cook2019 Herm Cook2019 Male Cook2020
MCL→mc2V 13 13 2.5
MCL→mc2DR 7 7 7

Electrical synaptic connections from/to MCL

M2L↔MCLM2R↔MCLM3L↔MCLM3R↔MCLMI↔MCL00.511.52
DatasetWhite_wholeCook2019 HermCook2019 MaleCook2020WormNeuroAtlasConnectionWeight
White_whole Cook2019 Herm Cook2019 Male Cook2020 WormNeuroAtlas
M2L↔MCL 2 1 1 1 2
M2R↔MCL 2 0 0 0 2
M3L↔MCL 1 0 0 0 1
M3R↔MCL 1 0 0 0 1
MI↔MCL 2 0 0 0 2

Monoaminergic connections to MCL

HSNL→MCLHSNR→MCLNSML→MCLNSMR→MCLRIML→MCLRIMR→MCLADFL→MCLADFR→MCL00.511.52
DatasetBentley2016_MAConnectionWeight
Bentley2016_MA
HSNL→MCL 1
HSNR→MCL 1
NSML→MCL 1
NSMR→MCL 1
RIML→MCL 1
RIMR→MCL 1
ADFL→MCL 1
ADFR→MCL 1

Peptidergic connections to MCL

NSML→MCLMI→MCLM4→MCLI3→MCLAIYL→MCLALA→MCLASHR→MCLAUAR→MCLBAGR→MCLDB1→MCLDB3→MCLDB5→MCLDB7→MCLHSNL→MCLOLLL→MCLPDA→MCLPHCR→MCLPVDL→MCLPVM→MCLPVNR→MCLAVAR→MCLAVBR→MCLAVER→MCLAVKR→MCLRMDR→MCLRIMR→MCLRIH→MCLRMFR→MCLSABVL→MCLSIBDL→MCLSIBVL→MCLURBL→MCLVA4→MCLVA6→MCLVA8→MCLVB1→MCLURXL→MCLVA1→MCLVA11→MCLVA2→MCLVB6→MCLVB4→MCLVB2→MCLVB8→MCLVB9→MCLVC2→MCLVC4→MCLVC6→MCLRIVR→MCLM2R→MCLAVL→MCLOLQDR→MCLIL1R→MCLIL1DR→MCLOLQVR→MCLIL1VR→MCL00.511.522.53
DatasetBentley2016_PEPRipollSanchezShortRangeRipollSanchezMidRangeRipollSanchezLongRangeConnectionWeight
Bentley2016_PEP RipollSanchezShortRange RipollSanchezMidRange RipollSanchezLongRange
NSML→MCL 0 1 1 1
I4→MCL 0 1 1 1
MI→MCL 0 1 1 1
NSMR→MCL 0 1 1 1
M4→MCL 0 1 1 1
M5→MCL 0 1 1 1
I3→MCL 0 1 1 1
AVAL→MCL 1 0 0 0
AIYL→MCL 1 0 0 0
AIYR→MCL 1 0 0 0
ALA→MCL 3 0 2 2
ASHL→MCL 1 0 0 0
ASHR→MCL 1 0 0 0
AUAL→MCL 1 0 1 1
AUAR→MCL 1 0 1 1
BAGL→MCL 1 0 0 0
BAGR→MCL 1 0 0 0
DA9→MCL 1 0 0 0
DB1→MCL 1 0 0 0
DB2→MCL 1 0 0 0
DB3→MCL 1 0 0 0
DB4→MCL 1 0 0 0
DB5→MCL 1 0 0 0
DB6→MCL 1 0 0 0
DB7→MCL 1 0 0 0
DVA→MCL 1 0 0 0
HSNL→MCL 1 0 2 2
HSNR→MCL 1 0 2 2
OLLL→MCL 1 0 0 0
OLLR→MCL 1 0 0 0
PDA→MCL 1 0 0 0
PHCL→MCL 1 0 0 1
PHCR→MCL 1 0 0 1
PQR→MCL 1 0 0 1
PVDL→MCL 1 0 0 1
PVDR→MCL 1 0 0 1
PVM→MCL 1 0 0 1
PVNL→MCL 1 0 0 0
PVNR→MCL 1 0 0 0
RIGL→MCL 1 0 0 0
AVAR→MCL 1 0 0 0
AVBL→MCL 1 0 0 0
AVBR→MCL 1 0 0 0
AVEL→MCL 1 0 0 0
AVER→MCL 1 0 0 0
AVKL→MCL 1 0 1 1
AVKR→MCL 1 0 1 1
RMFL→MCL 2 0 1 1
RMDR→MCL 1 0 0 0
RMDL→MCL 1 0 0 0
RIMR→MCL 1 0 0 0
RIML→MCL 1 0 0 0
RIH→MCL 1 0 0 0
RIGR→MCL 1 0 0 0
RMFR→MCL 2 0 1 1
URBR→MCL 1 0 1 1
SABVL→MCL 1 0 0 0
SABVR→MCL 1 0 0 0
SIBDL→MCL 1 0 0 0
SIBDR→MCL 1 0 0 0
SIBVL→MCL 1 0 0 0
SIBVR→MCL 1 0 0 0
URBL→MCL 1 0 1 1
VA3→MCL 1 0 1 1
VA4→MCL 1 0 1 1
VA5→MCL 1 0 0 1
VA6→MCL 1 0 0 1
VA7→MCL 1 0 0 1
VA8→MCL 1 0 0 1
VA9→MCL 1 0 0 1
VB1→MCL 2 0 0 0
VB10→MCL 2 0 0 1
URXL→MCL 1 0 1 1
URXR→MCL 1 0 1 1
VA1→MCL 1 0 1 1
VA10→MCL 1 0 0 1
VA11→MCL 1 0 0 1
VA12→MCL 1 0 0 0
VA2→MCL 1 0 1 1
VB7→MCL 2 0 0 1
VB6→MCL 2 0 0 1
VB5→MCL 2 0 0 1
VB4→MCL 2 0 0 1
VB3→MCL 2 0 0 1
VB2→MCL 2 0 1 1
VB11→MCL 2 0 0 1
VB8→MCL 2 0 0 1
AINL→MCL 1 0 1 1
VB9→MCL 2 0 0 1
VC1→MCL 1 0 1 1
VC2→MCL 1 0 1 1
VC3→MCL 1 0 0 1
VC4→MCL 1 0 0 1
VC5→MCL 1 0 0 1
VC6→MCL 1 0 0 1
OLQDL→MCL 2 0 1 1
RIVR→MCL 1 0 0 0
RIVL→MCL 1 0 0 0
M2R→MCL 1 0 0 0
M2L→MCL 1 0 0 0
AVL→MCL 1 0 0 0
AINR→MCL 1 0 1 1
OLQDR→MCL 2 0 1 1
IL1VL→MCL 1 0 1 1
IL1R→MCL 1 0 1 1
IL1L→MCL 1 0 1 1
IL1DR→MCL 1 0 1 1
IL1DL→MCL 1 0 1 1
OLQVR→MCL 2 0 1 1
OLQVL→MCL 2 0 1 1
IL1VR→MCL 1 0 1 1

Peptidergic connections from MCL

MCL→MIMCL→AIBRMCL→AIYRMCL→ALMLMCL→AS10MCL→AS4MCL→AS8MCL→ASGLMCL→ASKLMCL→AVALMCL→AVDLMCL→AVFLMCL→AVMMCL→AWBRMCL→BDURMCL→DA4MCL→ADALMCL→DB2MCL→DB7MCL→HSNRMCL→I4MCL→LUALMCL→M5MCL→PLMRMCL→PVCLMCL→PVMMCL→PVQRMCL→PVWRMCL→RIBRMCL→RIFLMCL→RIHMCL→RMDDLMCL→RMDVLMCL→RMEVMCL→SAADLMCL→SABVLMCL→SMBDLMCL→SMDDLMCL→URBLMCL→VA1MCL→VA2MCL→VA5MCL→VB1MCL→VB3MCL→VB7MCL→ADARMCL→AVHLMCL→ADLRMCL→SABD012345
DatasetBentley2016_PEPRipollSanchezShortRangeRipollSanchezMidRangeRipollSanchezLongRangeConnectionWeight
Bentley2016_PEP RipollSanchezShortRange RipollSanchezMidRange RipollSanchezLongRange
MCL→MI 1 1 1 1
MCL→M3L 1 1 1 1
MCL→M3R 1 1 1 1
MCL→I5 3 1 1 1
MCL→AIBR 2 0 0 0
MCL→AIML 3 0 1 1
MCL→AIMR 3 0 1 1
MCL→AIYL 3 0 0 0
MCL→AIYR 3 0 0 0
MCL→AIZL 3 0 1 1
MCL→AIZR 3 0 1 1
MCL→ALA 1 0 0 0
MCL→ALML 1 0 0 0
MCL→ALMR 1 0 0 0
MCL→AQR 2 0 1 1
MCL→AS1 2 0 1 1
MCL→AS10 2 0 0 1
MCL→AS11 2 0 0 1
MCL→AS2 2 0 1 1
MCL→AS3 2 0 0 1
MCL→AS4 2 0 0 1
MCL→AS5 2 0 0 1
MCL→AS6 2 0 0 1
MCL→AS7 2 0 0 1
MCL→AS8 2 0 0 1
MCL→AS9 2 0 0 1
MCL→ASEL 1 0 1 1
MCL→ASER 2 0 1 1
MCL→ASGL 3 0 1 1
MCL→ASGR 3 0 1 1
MCL→ASHL 1 0 1 1
MCL→ASHR 1 0 1 1
MCL→ASKL 2 0 0 0
MCL→ASKR 2 0 0 0
MCL→AUAL 1 0 1 1
MCL→AUAR 1 0 1 1
MCL→AVAL 1 0 0 0
MCL→AVAR 1 0 0 0
MCL→AVBL 1 0 0 0
MCL→AVBR 1 0 0 0
MCL→AVDL 4 0 0 0
MCL→AVDR 4 0 0 0
MCL→AVEL 3 0 0 0
MCL→AVER 3 0 0 0
MCL→AVFL 3 0 0 0
MCL→AVFR 3 0 0 0
MCL→AVKL 1 0 0 0
MCL→AVKR 1 0 0 0
MCL→AVM 1 0 0 0
MCL→AWAL 1 0 1 1
MCL→AWAR 1 0 1 1
MCL→AWBL 2 0 2 2
MCL→AWBR 2 0 2 2
MCL→BAGL 1 0 1 1
MCL→BAGR 1 0 1 1
MCL→BDUL 3 0 1 1
MCL→BDUR 3 0 1 1
MCL→DA1 3 0 0 0
MCL→DA2 3 0 0 0
MCL→DA3 3 0 0 0
MCL→DA4 3 0 0 0
MCL→DA5 3 0 0 0
MCL→DA6 3 0 0 0
MCL→DA7 3 0 0 0
MCL→ADAL 1 0 0 0
MCL→ADFL 3 0 1 1
MCL→ADFR 3 0 1 1
MCL→AIBL 2 0 0 0
MCL→DB2 3 0 0 0
MCL→DB1 3 0 1 1
MCL→DA9 4 0 0 1
MCL→DA8 3 0 0 0
MCL→DB7 3 0 0 0
MCL→DVA 2 0 1 1
MCL→DB5 3 0 0 0
MCL→DB3 3 0 0 0
MCL→HSNR 1 0 0 0
MCL→I1L 3 0 0 0
MCL→I3 2 0 0 0
MCL→I1R 3 0 0 0
MCL→I4 2 0 0 0
MCL→IL2L 2 0 2 2
MCL→HSNL 1 0 0 0
MCL→DB4 3 0 0 0
MCL→LUAL 1 0 0 0
MCL→IL2R 2 0 2 2
MCL→M1 2 0 0 0
MCL→LUAR 1 0 0 0
MCL→M5 2 0 0 0
MCL→PDA 3 0 0 1
MCL→PDB 4 0 0 1
MCL→PLML 1 0 0 0
MCL→PLMR 1 0 0 0
MCL→PLNL 1 0 1 1
MCL→PLNR 1 0 1 1
MCL→PQR 5 0 0 2
MCL→PVCL 2 0 1 1
MCL→PVCR 2 0 1 1
MCL→PVDL 3 0 0 1
MCL→DB6 3 0 0 0
MCL→PVM 4 0 0 1
MCL→PVPL 2 0 1 1
MCL→PVPR 2 0 1 1
MCL→PVQL 3 0 1 1
MCL→PVQR 3 0 1 1
MCL→PVR 4 0 1 1
MCL→PVT 2 0 0 0
MCL→PVWL 2 0 0 0
MCL→PVWR 2 0 0 0
MCL→RIAL 1 0 0 0
MCL→RIAR 1 0 0 0
MCL→RIBL 1 0 0 0
MCL→RIBR 1 0 0 0
MCL→RICL 3 0 0 0
MCL→RICR 3 0 0 0
MCL→RID 3 0 0 0
MCL→RIFL 1 0 1 1
MCL→RIFR 1 0 1 1
MCL→RIGL 4 0 2 2
MCL→RIGR 4 0 2 2
MCL→RIH 5 0 2 2
MCL→RIML 1 0 0 0
MCL→RIMR 1 0 0 0
MCL→RIR 3 0 1 1
MCL→RMDDL 3 0 0 0
MCL→RMDDR 3 0 0 0
MCL→RMDL 2 0 0 0
MCL→RMDR 2 0 0 0
MCL→RMDVL 3 0 0 0
MCL→RMDVR 3 0 0 0
MCL→RMED 1 0 0 0
MCL→PVDR 3 0 0 1
MCL→RMEV 1 0 0 0
MCL→RMGL 1 0 1 1
MCL→RMHL 1 0 0 0
MCL→RMGR 1 0 1 1
MCL→SAADL 1 0 1 1
MCL→SAADR 1 0 1 1
MCL→SAAVL 1 0 1 1
MCL→RMHR 1 0 0 0
MCL→SABVL 2 0 1 1
MCL→SABVR 2 0 1 1
MCL→SDQL 1 0 0 0
MCL→SDQR 1 0 0 0
MCL→SMBDL 1 0 1 1
MCL→SMBDR 1 0 1 1
MCL→SMBVL 1 0 1 1
MCL→SAAVR 1 0 1 1
MCL→SMDDL 3 0 0 0
MCL→SMDDR 3 0 0 0
MCL→SMDVL 3 0 0 0
MCL→SMDVR 3 0 0 0
MCL→URBL 4 0 1 1
MCL→URBR 4 0 1 1
MCL→URXL 4 0 1 1
MCL→URXR 4 0 1 1
MCL→VA1 1 0 0 0
MCL→VA10 1 0 0 0
MCL→VA11 1 0 0 0
MCL→VA12 4 0 0 1
MCL→VA2 1 0 0 0
MCL→VA3 1 0 0 0
MCL→VA4 1 0 0 0
MCL→SMBVR 1 0 1 1
MCL→VA5 1 0 0 0
MCL→VA6 1 0 0 0
MCL→VA8 1 0 0 0
MCL→VA7 1 0 0 0
MCL→VB1 3 0 2 2
MCL→VB10 3 0 0 0
MCL→VB11 3 0 0 0
MCL→VA9 1 0 0 0
MCL→VB3 3 0 0 0
MCL→VB4 3 0 0 0
MCL→VB5 3 0 0 0
MCL→VB6 3 0 0 0
MCL→VB7 3 0 0 0
MCL→VB8 3 0 0 0
MCL→VB9 3 0 0 0
MCL→VB2 3 0 1 1
MCL→ADAR 1 0 0 0
MCL→AINL 1 0 1 1
MCL→ASJL 1 0 1 1
MCL→AINR 1 0 1 1
MCL→AVHL 1 0 0 0
MCL→AVHR 1 0 0 0
MCL→ADLL 1 0 0 0
MCL→ASJR 1 0 1 1
MCL→ADLR 1 0 0 0
MCL→AVJL 1 0 1 1
MCL→AVJR 1 0 1 1
MCL→DVB 1 0 0 1
MCL→SABD 1 0 1 1
MCL→URYVL 1 0 0 0
MCL→CANL 0 0 0 1
MCL→CANR 0 0 0 1

Acetylcholine connections to MCL

I1L→MCLI1R→MCLI3→MCL11.21.41.61.82
DatasetWormNeuroAtlasConnectionWeight
WormNeuroAtlas
I1L→MCL 2
I1R→MCL 2
I3→MCL 1

Functional connections to MCL

NSMR→MCLM3L→MCLM3R→MCLI4→MCL0.120.140.160.180.2
DatasetRandi2023ConnectionWeight
Randi2023
NSMR→MCL 0.201942
M3L→MCL 0.158783
M3R→MCL 0.122947
I4→MCL 0.116364

Functional connections from MCL

MCL→NSMRMCL→I2LMCL→NSMLMCL→I2RMCL→BAGLMCL→M3LMCL→AVJL−0.0500.050.10.150.20.250.3
DatasetRandi2023ConnectionWeight
Randi2023
MCL→NSMR 0.318004
MCL→I2L 0.294716
MCL→NSML 0.258218
MCL→I2R 0.201318
MCL→BAGL 0.15885
MCL→M3L 0.154566
MCL→AVJL -0.0502552